Novobiocin attacks BRCA-mutated cancer cells from within and without, study shows danafarber NatureComms
They found the drug causes tumor cells to become increasingly riddled with micronuclei—miniature nuclei that contain damaged fragments of chromosomes. The chromosome pieces slip easily through gaps in the micronuclei membranes and into the cells' cytoplasm, activating a protein pathway known as cGAS/STING.
One of the ways that the tumor cells adapt to the presence of novobiocin is by upping their production of the PD-L1 protein, which helps fend off a T-cell attack, Shapiro continues. This suggests that combining novobiocin with a PD-1-blocking agent could be more effective than novobiocin alone. Investigators hope to launch a clinical trial of the combination in the future.
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