SLE affects about nine females for every one male suggesting that hormones are involved in the pathogenesis of the disease. It also suggests that the X chromosome might play a role. RheumTwitter
, or lupus, shows a marked sex bias, affecting about nine females for every one male, according to Susan Kovats, PhD, who studies sex differences in immunity at the Oklahoma Medical Research Foundation in Oklahoma City. This characteristic of lupus suggests that hormones are involved in the pathogenesis of the disease. It also suggests, Kovats said, that the X chromosome might play a role.
Kovats agreed that it was a useful approach."The transgender people provided an opportunity to effectively separate sex hormone levels from chromosome content," she said in an interview.Peripheral blood mononuclear cell samples were taken from cisgender individuals with and without juvenile-onset lupus and assessed for 28 immune-cell subsets, including different T-cell, B-cell, and monotype subsets.
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