Katalin Kariko and Drew Weissman discovered a key step toward making mRNA vaccines
Katalin Kariko and Drew Weissman won the Nobel Prize in medicine for their discoveries that enabled the creation of mRNA vaccines.t was an unlikely collaboration, and it began in an unlikely place, but the partnership that Katalin Kariko and Dr. Drew Weissman formed in the 1990s at the University of Pennsylvania has now led to a shared Nobel Prize in Physiology and Medicine.
True to their long-time partnership, Kariko then called Weissman to break the good news. In fact, the early morning call likely reminded him of years of similar emails he and Kariko would exchange at dawn when they were working to crack the problem of turning mRNA into reliable therapies. To make mRNA a useful tool for treating people, however, Kariko needed to find a way to suppress its tendency to aggravate the immune system, which ended up creating a dangerous inflammatory reaction and destroying the very mRNA that was supposed to be therapeutic. Their personalities couldn't be more different—according to Kariko, Weissman said she tended to zig and zag to generate ideas, while he preferred the more straightforward approach.
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