The discovery could pave the way for treating substance use disorders. In a rat model of impulsive behavior, researchers discovered that inhibiting certain acetylcholine receptors in the lateral habenula (LHb), a region of the brain responsible for balancing reward and aversion, made it more diffic
New brain mechanisms linked to rats’ impulsive cocaine craving have been discovered by National Institutes of Health researchers.In a rat model of impulsive behavior, researchers discovered that inhibiting certain acetylcholine receptors in the lateral habenula , a region of the brain responsible for balancing reward and aversion, made it more difficult to resist the urge to seek cocaine.
Because the LHb serves as an interface between brain areas mediating emotion and reward and those involved with reasoning and other higher-order thought processes, factors known to be associated with substance use disorders and major depressive disorders, addiction science researchers are particularly interested in the LHb as a target for the development of future treatments.
In this model, rats were trained to self-administer cocaine, where a lever press led to an injection of the drug. This was followed by specific training in the Go/NoGo task where cocaine was available when the lights were on , but not when the lights were off . Animals quickly learned to stop responding when cocaine was not available.
Thus, when M2Rs were blocked in the LHb the rodents were no longer able to stop responding to cocaine even when it was not available , despite the training. This indicates that increasing LHb M2R function may represent a potential target for treating impulsive drug seeking and substance use disorders.
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