Researchers have discovered a new signaling molecule that forces brown fat cells to consume more energy. Typically, fat cells store energy. However, energy is lost as heat in brown fat cells, making brown fat a biological heater. This mechanism is consequently present in most mammals. In humans, br
The researchers believe that their discovery could one day be used as a treatment for obesity.
“Nowadays, however, we’re toasty warm even in winter,” explains Prof. Dr. Alexander Pfeifer from the Institute of Pharmacology and Toxicology at the University of Bonn. “So our body’s own furnaces are hardly needed anymore.” The researchers, therefore, studied brown fat cells subjected to severe stress, so that the cells were virtually dying.However, what was more intriguing was the way that intact brown fat cells reacted to the molecular cry for assistance: they were activated by inosine . Inosine thus fanned the furnace inside them. White fat cells also converted to their brown siblings.
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