New technique opens the door to safer gene editing by reducing the mutation problem in gene therapy NagoyaUniv_info natBME
Now, researchers at Kyushu University in southern Japan and Nagoya University School of Medicine in central Japan have developed an optimized genome-editing method that vastly reduces mutations, opening the door to more effective treatments of genetic diseases. Their findings were published inGenome-editing technology centered on CRISPR-Cas9 has revolutionized the food and medical industries.
To test this hypothesis, a group consisting of Assistant Professor Masaki Kawamata at Kyushu University and Professor Hiroshi Suzuki at the Nagoya University Graduate School of Medicine constructed a system called"AIMS" in mouse cells, which evaluated the activity of Cas9 separately for each chromosome. Their results showed that the commonly used method was associated with very high editing activity.
Their results were striking. Using their new technique, off-target effects and cytotoxicity were reduced, the efficiency of single-allele selective editing was increased, and the efficiency of homology-directed repair, the most commonly employed mechanism for DNA double-strand break repair, was enhanced.
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