Improved protein function opens the door to novel drug development possibilities. In a paper that was published in the journal Science, scientists from Sweden's Karolinska Institutet and SciLifeLab reveal how they were able to enhance a protein's ability to repair oxidative DNA damage while als
damage while also creating a new protein function. The researchers’ ground-breaking technique may result in better treatments for oxidative stress-related illnesses such as cancer,Finding certain pathogenic proteins and developing medicines that inhibiting these proteins has long been the foundation of the drug development process. However, many illnesses are caused by a reduction or loss of protein function, which cannot be specifically targeted by inhibitors.
The researchers examined how such catalyst molecules, previously described by others, bind to OGG1 and affect its function in cells. One of the molecules proved to be of particular interest.“When we introduce the catalyst into the enzyme, the enzyme becomes ten times more effective at repairing oxidative DNA damage and can perform a new repair function,” says the study’s first author Maurice Michel, assistant professor at the Department of Oncology-Pathology, Karolinska Institutet.
The catalyst made it possible for the enzyme to cut the DNA in an unusual way so that it no longer requires its regular protein APE1 to work but another protein called PNKP1.
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