New subtypes identified in difficult-to-treat ovariancancer helsinkiuni
The researchers were able to classify HGSC tumors into three groups on the basis of genomic changes. The groups differ in the intracellular signaling pathways, the ways in which the tumors grow, and response to treatment.
The researchers identified signaling pathways characteristic of each tumor group, which make these tumors biologically distinct. . Based on our findings, we are better able to identify the subset of patients likely to benefit from such treatment," says Postdoctoral Researcher Jaana Oikkonen from the University of Helsinki.The study approaches the issue from the perspective of tumor evolution, or how the tumor develops and spreads into new metastases. This approach is currently important in research on HGSC as the knowledge available is largely based on studies with small sample or patient numbers.
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