Researchers at the University of Bonn have uncovered clues to the underlying causes of the condition. Cleft lip and palate are common congenital malformations that have been linked to genetic causes, although the specific genes involved have not yet been identified. A recent study led by the Univer
Cleft lip and cleft palate are birth defects that occur when the tissue that forms the lip and roof of the mouth do not fuse together properly during development. Cleft lip is a gap or split in the upper lip, while cleft palate is a gap or split in the roof of the mouth.
The researchers furthermore used novel data analysis methods to find evidence that the transcription factor Musculin also plays a role. “This suggests an involvement of embryonic development of facial muscles in cleft lip and palate,” says lead author Hanna Zieger, a member of Ludwig’s team. “This had previously been suspected, but not yet demonstrated.”
With her specially tailored evaluation methods, Zieger was able to show that the base sequence of the binding sites of Musculin is altered more often and to a greater extent in patients than in the control group. “The evaluation script written by Ms. Zieger can also be used for other diseases,” says Ludwig, who is a member of the Cluster of Excellence ImmunoSensation2.
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