New RSV vaccine may prevent illness in infants, seniors nejm
"For me personally, this is a dream come true," said Gruber, a co-author of bothclinical trial reports."I've been working in this field looking for a major advance in RSV for probably 40 years. This is a really fantastic advance, I think, for world health."
Each year, between 58,000 and 80,000 children under age 5 are hospitalized due to an RSV infection, the CDC says. RSV hit the U.S. particularly hard during the last cold and flu season, as pandemic social isolation restrictions were lifted. The virus tore through populations of young children who had never been exposed to it, and, therefore, had weak immunity against it.
The Pfizer and GSK vaccines both target RSV's F protein, which the virus uses to attach to and invade human cells.Attempts to create an RSV vaccine in the 1960s failed. That earlier vaccine caused a phenomenon called antibody-dependent enhancement, where the antibodies produced by a vaccine actually make a virus more virulent and harmful. Two children died in the clinical trial.
This breakthrough prompted a race among Pfizer, GSK and other pharmaceutical companies to craft a safe and effective RSV vaccine.
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