New research sheds light on gut-kidney axis in diabetes and diabetic nephropathy SciReports diabetic diabetes gutkidneyaxis microbiome gutmicrobiome
By Hugo Francisco de SouzaAug 2 2023Reviewed by Lily Ramsey, LLM In a recent study published in the Scientific Reports Journal, researchers explored gut microbiota composition to evaluate the association between the microbes and diabetic clinical phenotypes, including neuropathy.
Diabetic neuropathy and gut microbiota Diabetes is a condition characterized by abnormally high blood glucose. Diabetes is ubiquitous, with reports from China indicating 11.2% between 2015-2017 and more recent global announcements estimating that more than 10% of individuals between the ages of 20-79 are afflicted.
Some proteins, metabolites, and toxins have been suggested to play a role in kidney health. Still, research has ignored the association between patterns and functional changes in gut flora and diabetes pathology. Pathological classification of DN was carried out by evaluating kidney damage by mesangial matrix , glomerular volume , glomerulosclerosis , glomerular basement membrane , and interstitial lesions .
These results suggest that gut microbial communities of T2DM and DN patients were significantly altered from NC individuals. Gemmiger spp. was similarly sufficient in distinguishing NC from T2DM cohorts, while DM and T2DM cohorts could be separated by evaluating the richness of Flavonifractor and Eisenbergiella genera.
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