Agilus, a new hybrid medicine, has been developed for the treatment of malignant hyperthermia, a rare disorder that causes overstimulation of skeletal muscles. It contains the same active substances as Dantrolen IV 20 mg but with improved formulation for easier use.
Malignant hyperthermia is a rare disorder in which skeletal muscles are overstimulated and unable to relax. Sudden onset can be triggered by, or occasionally by stresses such as vigorous exercise or heat. Malignant hyperthermia can be life-threatening because it causes a rapid rise in body temperature and/or metabolic acidosis. Agilus is a hybrid medicine of muscle relaxant dantrolene sodium (Dantrolen IV 20 mg), which has been authorized in the European Union since 1984.
It works by binding to the ryanodine receptor 1, preventing release of calcium from the sarcoplasmic reticulum. Agilus contains the same active substances as Dantrolen IV 20 mg but will be available in a 120-mg powder for solution for injection. In the formulation of Agilus, theand sodium hydroxide have been replaced with hydroxypropyl-beta-cyclodextrin and Macrogol 3350 to shorten the preparation time and improve ease of us
Malignant Hyperthermia Hybrid Medicine Agilus Skeletal Muscles Dantrolene Sodium
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