Research from the University of Kansas published in Proceedings of the National Academy of Sciences could hasten development of a new class of vaccines aimed at SARS-CoV-2, the virus that causes COVID-19.
SARS-CoV-2 nonstructural protein three domains and location of Mac1 in SARS-CoV-2 genome. Cartoon diagram illustrating the different domains of SARS-CoV-2 nsp3. Schematic of the SARS-CoV-2 genome with location of Mac1, indicating the area of the Mac1 deletion and the point mutations that were engineered. Credit:Research from the University of Kansas published incould hasten development of a new class of vaccines aimed at SARS-CoV-2, the virus that causes COVID-19.
Studying how SARS-CoV-2 behaved in mouse models, Fehr's collaborator at Oklahoma State, Rudra Channappanavar and his group, found that without Mac1, the virus barely had an impact on the health of mice. "Right now, we're really looking at further developing this virus into a live attenuated vaccine for SARS-CoV-2, and we're working on different strategies with minor modifications to this virus to make it even better," he said."We think this is a great start to developing a vaccine that we think would have longer lasting immunity.
"I don't want to diss mRNA vaccines—they're great," Fehr said."But they're not particularly long-lasting. We're finding their immunity wanes over the course of time. Live-attenuated viruses have been around for decades, and many of them are very effective and last very long. We can get a lot of live-attenuated vaccines as children, and we never have to take them again because they last our lifetime.
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