An experimental Alzheimer’s drug modestly slowed the brain disease’s inevitable worsening, researchers reported -- but it remains unclear how much difference that might make in people’s lives.
But doctors are divided over how much difference those changes may make for patients and families.
But Dr. Ron Petersen, an Alzheimer’s expert at the Mayo Clinic, said the drug’s effect was “a modest one but I think it’s clinically meaningful” -- because even a few months’ delay in progression could give someone a little more time when they’re functioning independently. But any delay in cognitive decline early on could be meaningful for “how much time we have with our loved ones in a stage of disease where we can still enjoy family and outings, vacations, bucket lists,” she said.
But Mayo’s Petersen said if lecanemab is approved for use in the U.S., he’d avoid prescribing it to people on blood thinners at least initially. Nearly all treatments available for the 6 million Americans with Alzheimer’s — and millions more worldwide — only temporarily ease symptoms. Scientists don’t yet know exactly how Alzheimer’s forms but one theory is that gunky amyloid buildup plays a key role, although drug after drug that targets it has failed.
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