A team of Harvard and Sloan Kettering scientists has developed compounds that can target and degrade proteins associated with acute myeloid leukemia (AML) and nearly doubled the life expectancy of mice with cancer in laboratory tests.
"Developing new molecules that degrade new targets for different types of cancer is a massive area of ongoing research in the
Research assistants David Miyamoto and Nicole Curnutt work with Associate Professor Christina Woo to create protein-degradation strategies that will be useful in developing cancer treatments. Credit: Kris Snibbe/Harvard Staff Photographer With their expertise in targeted protein degradation and this class of molecules, Woo's lab generated a series of compounds and tested them in
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