Science, Space and Technology News 2024
Researchers have developed a new method for engineering enzymes more effectively by utilizing an algorithm that considers their evolutionary history. This method enables targeted mutations that enhance enzyme performance and stability. The approach has been demonstrated on the enzyme beta-lactamase, showing that substantial modifications in amino acid sequences can improve functionality without altering the enzyme’s structure.
– could have significant, wide-ranging impacts across a suite of industries, from food production to human health. Here, the scientists report a promising new strategy to rationally engineer an enzyme called “beta-lactamase”. Instead of introducing random mutations in a scattergun approach, researchers at the Broad Institute and Harvard Medical School developed an algorithm that takes into account the evolutionary history of the enzyme.“At the heart of this new algorithm is a scoring function that exploits thousands of sequences of beta-lactamase from many diverse organisms.
Her 3D map revealed that despite changes to 30% of the amino acids, the enzyme had an identical structure to the wild-type beta-lactamase. It also revealed how coordinated changes in amino acids, introduced simultaneously, can efficiently stabilize the 3D structure – in contrast to individual changes that typically impair the enzyme structure.
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