New technique allows researchers to dig into molecular causes of pediatric bipolar disorder uofuhealthcare MolPsychiatry
Pediatric bipolar disorder is a severe mood dysregulation condition that affects 0.5–1% of children and teens in the United States. It is associated with recurrent episodes of mania and depression and an increased risk of suicidality. However, the genetics and neuropathology of PBD are largely unknown. Here, we used a combinatorial family-based approach to characterize cellular, molecular, genetic, and network-level deficits associated with PBD.
Using transcriptomic profiling of patient and control induced pluripotent stem cell -derived telencephalic organoids, we found aberrant signaling in the molecular pathways related to neurite outgrowth.
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