Synonymous mutations have a harmful effect on yeast-cell fitness.
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Mutations matter even if proteins stay the sameSynonymous mutations have a harmful effect on yeast-cell fitness.
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Synonymous mutations in representative yeast genes are mostly strongly non-neutral - NatureA survey of 8,341 mutations in 21 yeast genes shows that synonymous mutations are nearly as harmful as nonsynonymous mutations, in part because they both affect the mRNA level of the gene mutated.
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