Mutations across animal kingdom shed new light on aging
The first study to compare the accumulation of mutations across many animal species has shed new light on decades-old questions about the role of these genetic changes in ageing and cancer. Researchers from the Wellcome Sanger Institute found that despite huge variation in lifespan and size, different animal species end their natural life with similar numbers of genetic changes., analysed genomes from 16 species of mammal, from mice to giraffes.
In this study, researchers at the Wellcome Sanger Institute set out to test these theories by using new methods to measure somatic mutation in 16 mammalian species, covering a wide range of lifespans and body masses. This included species such as human, mouse, lion, giraffe, tiger, and the long-lived, highly cancer-resistant naked mole-rat, with samples provided by a number of organisations including the Zoological Society of London.
Dr Alex Cagan, a first author of the study from the Wellcome Sanger Institute, said:"To find a similar pattern of genetic changes in animals as different from one another as a mouse and a tiger was surprising. But the most exciting aspect of the study has to be finding that lifespan is inversely proportional to the somatic mutation rate. This suggests that somatic mutations may play a role in ageing, although alternative explanations may be possible.
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