Monkeypox response relies on three vaccine suppliers - CharlotteH560
to attenuate its neurotoxicity but still strongly protect with a single dose, as demonstrated in animal models.such as myocarditis and pericarditis are still a concern.
Lederman says that horsepox is closer to the pox strain used by vaccine pioneer Edward Jenner and avoids mutations that have accumulated over centuries of pox-based. “Jenner’s live-virus vaccine is the most successful vaccine ever. It eradicated smallpox and provides nearly lifelong immunity with no booster,” he says.
“During Jenner’s time in the early nineteenth century, inocula derived from either cowpox or horsepox were used interchangeably for smallpox vaccination, taking advantage of what we now know: that all poxviruses lead to cross-species immunity.”in collaboration with the Kenya Medical Research Institute in 2023. Although cases of human monkeypox have not been reported in Kenya, it is close to regions where a high-mortality clade is endemic, and spread is anticipated.
EpiVax CEO and University of Georgia Professor Annie De Groot thinks the vaccine will drive T cell responses similar to those thought to underlie a large part of the efficacy of COVID-19 mRNA vaccines and prevent morbidity and mortality. But she hasn’t found a partner to trial this, despite having reached out to larger vaccine companies. “I’m sure the lack of positive response is because they view the market as being tiny compared [with] COVID,” she says.
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