Mount Sinai researchers have published one of the first studies to associate changes in blood gene expression during COVID-19 with “long COVID” in patients more than a year after they were hospitalized with severe COVID-19. Long COVID is the common name used for what is known more technically as pos
Mount Sinai researchers have published one of the first studies to associate changes in blood gene expression during COVID-19 with the post-acute sequelae of SARS-CoV-2 infection, also known as “long COVID,” in patients more than a year after they were hospitalized with severe COVID-19. Credit: Nature Medicine/Icahn School of Medicine at Mount Sinai
The research team identified, among other findings, two molecularly distinct subsets of long COVID symptoms with opposing gene expression patterns during acute COVID-19 incells, the immune system’s antibody-producing cells. In patients who went on to develop lung problems, antibody production genes were less abundant. However, for patients with other symptoms such as the loss of smell or taste and sleep disruptions, the same antibody production genes were more abundant instead.
Using the Mount Sinai COVID-19 Biobank, the researchers examined gene expression data in blood samples from more than 500 patients hospitalized with COVID-19 between April and June 2020. More than 160 of these patients provided self-reported assessments of symptoms still present six months or more after hospitalization.
The team said long COVID still remains poorly defined and future studies should take the initial stage of infection into account to more comprehensively characterize the molecular processes of long COVID and identify biomarkers that can help predict, treat, and prevent prolonged symptoms.
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