Moderna cancer vaccine with Merck's Keytruda delays return of deadly skin cancer
Moderna's vaccine is custom-built based on an analysis of a patient's tumors after surgical removal. The vaccines are designed to train the immune system to recognize and attack specific mutations in cancer cells.
There was little difference in response rates among people whose tumors had a lot of mutations - a typical predictor of immunotherapy response - and those whose tumors did not. Merck said the companies are in talks with U.S. regulators about the design of a late-stage trial, which is likely needed for approval of the combination regimen.
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