A study published in GenomeMedicine finds that gut microbiome differentiates individuals with a more severe disease course after infection with COVID-19 and may be a potential biomarker for disease severity. Further research is warranted.
Our study has several key strengths. First, we assembled a large representative cohort of patients at a U.S.-based tertiary care center for whom we collected relevant clinical metadata to complement serial stool sampling. Second, our computational workflow allowed us to not only link community-level changes in gut microbial ecology but species-resolved signatures of severe COVID-19, which we were able to validate in an external cohort of patients.
We acknowledge several limitations. We were not positioned to assess whether findings differed on the basis of SARS-CoV-2 strain or variants. Our study enrolled patients from April 2020 to May 2021 during which genomic surveillance infrastructure in the USA was not equipped to comprehensively explore this question. Prior to the Delta variant wave beginning in June 2021, the majority of COVID-19 cases were either Alpha or other less consequential variants of interest [].
Österreich Neuesten Nachrichten, Österreich Schlagzeilen
Similar News:Sie können auch ähnliche Nachrichten wie diese lesen, die wir aus anderen Nachrichtenquellen gesammelt haben.
Toxicology knowledge graph for structural birth defects - Communications MedicineClarke, Evangelista et al. use a knowledge graph (ReproTox-KG) to characterize associations between small molecule compounds and their potential to induce specific birth abnormalities. They identify over 500 birth defect/gene/drug connections that can explain molecular mechanisms for drug-induced birth defects.
Weiterlesen »
Clinical effects of Lewy body pathology in cognitively impaired individuals - Nature MedicineProspective and longitudinal analyses of patients with cognitive impairment reveal that in vivo detection of Lewy body pathology is independently associated with hallucinations, worse attention/executive, visuospatial and motor function and predicted future cognitive decline.
Weiterlesen »
In vivo quantitative MRI: T1 and T2 measurements of the human brain at 0.064 T - Magnetic Resonance Materials in Physics, Biology and MedicineObjective To measure healthy brain $${T}_{1}$$ T 1 and $${T}_{2}$$ T 2 relaxation times at 0.064 T. Materials and methods $${T}_{1}$$ T 1 and $${T}_{2}$$ T 2 relaxation times were measured in vivo for 10 healthy volunteers using a 0.064 T magnetic resonance imaging (MRI) system and for 10 test samples on both the MRI and a separate 0.064 T nuclear magnetic resonance (NMR) system. In vivo $${T}_{1}$$ T 1 and $${T}_{2}$$ T 2 values are reported for white matter (WM), gray matter (GM), and cerebrospinal fluid (CSF) for automatic segmentation regions and manual regions of interest (ROIs). Results $${T}_{1}$$ T 1 sample measurements on the MRI system were within 10% of the NMR measurement for 9 samples, and one sample was within 11%. Eight $${T}_{2}$$ T 2 sample MRI measurements were within 25% of the NMR measurement, and the two longest $${T}_{2}$$ T 2 samples had more than 25% variation. Automatic segmentations generally resulted in larger $${T}_{1}$$ T 1 and $${T}_{2}$$ T 2 estimates than manual ROIs. Discussion $${T}_{1}$$ T 1 and $${T}_{2}$$ T 2 times for brain tissue were measured at 0.064 T. Test samples demonstrated accuracy in WM and GM ranges of values but underestimated long $${T}_{2}$$ T 2 in the CSF range. This work contributes to measuring quantitative MRI properties of the human body at a range of field strengths.
Weiterlesen »
Covid-19 inquiry hears poorest were worst hit during pandemicPeople from less well-off backgrounds were more likely to be hospitalised during the pandemic, the Covid-19 inquiry in London hears MLChealth covid
Weiterlesen »
Unraveling the consequences: COVID-19's devastating effect on the TB care cascadeUnraveling the consequences: COVID-19's devastating effect on the TB care cascade medrxivpreprint StellenboschUni covid COVID19 SARSCoV2 TB tuberculosis healthequity LMICs
Weiterlesen »
Unveiling long COVID: new study explores symptoms and strain variationsUnveiling long COVID: new study explores symptoms and strain variations Life_MDPI longcovid covid COVID19 SARSCoV2 longCOVID symptoms strain
Weiterlesen »