Tadpoles exposed to a metabolism-disrupting herbicide had malformed intestines, providing clues to a human condition called intestinal malrotation.
Inside the African clawed frog, intestines grow just like humans’: neatly coiled counterclockwise. Experiments now show how that process can go awry.. Their findings offer new insight into how a similar birth anomaly in humans, known as intestinal malrotation, may occur.
“Think of the intestine as a garden hose,” says Nanette Nascone-Yoder, a developmental biologist at N.C. State. “You have to pay careful attention as you wind it up to avoid kinks and knots.” In frogs — and in people — the intestine typically winds counterclockwise as it develops. This happens early in a tadpole’s development, roughly between the third and fourth day. The researchers exposed). They found that many of the frogs’ intestines coiled clockwise — the wrong direction.
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