Multiple studies have demonstrated the memory-enhancing effects of melatonin and its derivatives in animal models. It is also known that the formation of both short- and long-term memories require the phosphorylation of certain memory-related proteins.
from Sophia University, Japan, have made important findings that contribute significantly to the elucidation of the underlying mechanisms in a recent article that was publishedRegarding the premise of the study, lead author Professor Atsuhiko Chiba from the Department of Materials and Life Sciences, Faculty of Science and Technology, Sophia University, says,"Our study aimed to investigate the effects of melatonin, ramelteon, and N1-acetyl-5-methoxyquinuramine on the relative...
In addition, they examined"phosphorylation," or the biochemical addition of phosphate groups to protein structures, in five key proteins involved in memory formation. These included the protein extracellular signal-regulated kinase , calcium/calmodulin-dependent kinase IIα , CaMKIIβ, CaMKIV, and the cAMP-response element binding protein .
Long-term memory formation in male mice was assessed by conducting a series of experiments based on the novel objection recognition task or"NORT." In this study, laboratory mice under investigation were first acclimated to an experimental arena for five minutes per day for three consecutive days. On the fourth day, two identical objects were placed in the experimental arena and mice were allowed to explore these objects for five minutes .were subjected to testing.
However, these drugs significantly decreased CaMKIIα/β phosphorylation in the same brain region. In the, which is also associated with memory functions, both ramelteon and AMK significantly increased ERK, and only ramelteon significantly increased CaMKIIβ phosphorylation. In the hippocampus/PRC, ramelteon/AMK did not affect the phosphorylation of CaMKIV.
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