A study in MicrobiomeJ finds that maternal western diet could alter the intestinal microbiota of offspring, leading to an increased susceptibility to Crohn’s disease-like colitis. Understanding the long-term effects of maternal diet can help prevent this.
: Table S1 and Table S2. Female mice were randomly assigned to dietary interventions, ensuring that body weight was similar between the two groups at study initiation. After 8 weeks of dietary exposure, the metabolic status of female mice was recorded.
To remove intestinal bile acid, the mice were orally administered a single dose of cholestyramine resin per day for 5 days prior to TNBS treatment.
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Maternal diet may be associated with the diet and body composition of their childrenMaternal diet may be associated with the diet and body composition of their children PLOSONE maternal pregnant diet nutrition womenshealth childrenshealth children infant
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Children of parents with different severities of mental health conditions have higher risk of somatic morbidity: a Danish nationwide register-based cohort study - BMC Public HealthBackground Children with the most severe parental mental health conditions have an elevated risk of numerous adversities including somatic morbidity. However, there is no knowledge concerning physical health in most children affected by parental mental health conditions. Therefore, the aim was to examine the association between different severities of parental mental health conditions and somatic morbidity in children of different age-groups and further explore the combinations of maternal and paternal mental health conditions on child somatic morbidity. Methods In this register-based cohort study, we included all children born in Denmark between 2000–2016 and linked parents. Parental mental health conditions were categorised into four severity groups (no, minor, moderate, and severe). Somatic morbidity in offspring was categorised into broad disease categories corresponding to the International Classification of Diseases. We estimated the risk ratio (RR) using Poisson regression, of the first registered diagnosis in different age-groups. Results Of the around 1 million children in the study | 14.5% were exposed to minor parental mental health conditions and | 2.3% were exposed to severe parental mental health conditions. Overall, the analyses revealed a higher risk of morbidity in exposed children across all disease categories. The strongest association was observed for digestive diseases in children aged | 1 year exposed to severe parental mental health conditions (RR: 1.87 (95% CI: 1.74–2.00). Generally, the risk of somatic morbidity increased the more severe the parental mental health conditions. Both paternal and especially maternal mental health conditions were associated with a higher risk of somatic morbidity. The associations were strongest if both parents had a mental health condition. Conclusion Children with different severities of parental mental health conditions experience a higher risk of somatic morbidity. Although children with severe parental ment
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Does birth setting impact birth outcome?In the USA, the vast majority of mothers deliver in hospitals, with less than 2% giving birth in birth centers or at home. However, few systematic attempts have been made to understand how the latter trend impacts maternal health. A new research paper published in the American Journal of Obstetrics and Gynecology uses available data to conclude that hospital births provide better perinatal outcomes in all cases, with increased benefits in high-risk pregnancies.
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Ukraine's Zelenskyy calls for 'jet coalition' as Sunak pledges hundreds of new attack dronesRishi Sunak has said the UK will be able to train Ukrainian pilots to use Western fighter jets 'relatively soon' as Volodymyr Zelenskyy reiterated calls for a 'jet coalition'.
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