“This is tremendously exciting and it suggests we have an entirely new way to treat prostate cancer on the horizon”
New ways to treat prostate cancer could be on the horizon after researchers figured out how to reverse the disease’s resistance to treatment in what has been hailed as a “major scientific advance”. It is hoped the work will lead to a greater understanding of what causes the disease to resist drugs and how to overcome it.
“This is tremendously exciting and it suggests we have an entirely new way to treat prostate cancer on the horizon.” For the study, published in Nature, the team recruited patients with advanced prostate cancer who had stopped responding to hormone therapy. It started after it observed that patients with aggressive and resistant forms of the disease had much higher levels of myeloid RNA in their blood. Its work has since shown that cells within tumours enter a “sleep state” known as senescence, transforming into “hormone factories” which support the growth of tumours.
He said the team is now planning to run a clinical trial. Professor Kristian Helin, chief executive of the ICR, said: “It’s fantastic to see such an innovative approach to treatment showing benefits in a clinical trial. It helps to act as a proof of principle for disrupting cancer’s supportive ecosystem as a smart new way of targeting tumours.
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