Blood test could predict future risk of leukemia, study finds NatureMedicine
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.. Sequence quality metrics for mutation calls across participants and time-points filtered for 2% VAF. Plotted are the AO ) against the UAO . Red dotted lines denote filter thresholds in both measurements and points are scaled by the VAF of the somatic mutation.
Prior distributions for the beta-binomial model for sequencing artefacts. Priors are constructed separately for mutations with a single occurrence and mutations with multiple observations in the LBCs .. Prior distribution of the proportion for the binomial model for sequencing artefacts. This prior is constructed only for mutations with a single occurrence in the LBC.. Effect of the Bayes Factor threshold on the number of non-synonymous variants selected as fit using LiFT.
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The current state of molecular profiling in gastrointestinal malignancies - Biology DirectThis is a review of the current state of molecular profiling in gastrointestinal (GI) cancers and what to expect from this evolving field in the future. Individualized medicine is moving from broad panel testing of numerous genes or gene products in tumor biopsy samples, identifying biomarkers of prognosis and treatment response, to relatively noninvasive liquid biopsy assays, building on what we have learned in our tumor analysis and growing into its own evolving predictive and prognostic subspecialty. Hence, the field of GI precision oncology is exploding, and this review endeavors to summarize where we are now in preparation for the journey ahead.
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Read an extract from I’m Sorry You Feel That Way by Rebecca WaitStylist Extra’s book of the week is I’m Sorry You Feel That Way by Rebecca Wait, which explores complicated sibling relationships and the effects of intergenerational trauma in sparkling prose.
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Evidence for anti-inflammatory effects and modulation of neurotransmitter metabolism by Salvia officinalis L. - BMC Complementary Medicine and TherapiesBackground Cognitive health is of great interest to society, with neuroinflammation and systemic inflammation age-related risk factors that are linked to declines in cognitive performance. Several botanical ingredients have been suggested to have benefits in this area including Salvia officinalis (sage), which has shown anti-inflammatory effects and exhibited promising cognitive improvements in multiple human studies. The current study demonstrates anti-inflammatory effects for S. officinalis across a broad set of in vitro models in human cells, and adds further evidence to support modulation of acetylcholine and monoamine neurostransmitter levels as mechanisms that contribute towards the benefits of the herb on cognitive health. Methods The effect of S. officinalis extract on release of multiple cytokines and chemokines was measured in human primary intestinal epithelial cells treated with or without LPS stimulation, and Blood Brain Barrier (BBB) cells in presence or absence of recombinant IL-17A and/or Human IL-17RA/IL-17R Antibody. Antioxidant effects were also assessed in BBB cells incubated with the extract and H2O2. The anti-inflammatory effects of S. officinalis extract were further assessed based on clinically-relevant biomarker readouts across 12 human primary cell-based disease models of the BioMAP Diversity PLUS panel. Results S. officinalis showed significant attenuation of the release of most cytokines/chemokines into apical media in LPS-stimulated intestinal cells, but small increases in the release of markers including IL-6, IL-8 in basolateral media; where TNF-α was the only marker to be significantly reduced. S. officinalis attenuated the release of CRP and VCAM-1 from BBB cells under IL-17A induced conditions, and also decreased H2O2 induced ROS overproduction in these cells. Phenotypic profiling with the BioMAP Diversity PLUS Panel identified additional anti-inflammatory mediators, and based on a similarity search analysis suggested potential mech
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Scarlett Moffatt reveals she's 'happier as a size 18' after fitness DVD scandalScarlett's Moffat has shared a picture of herself in a bikini for the first time in 5 years as she urges fans to 'celebrate' their bodies.
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Paw-some new dog fitness swimming pool opening in LincolnshireFun and fitness for pooches!
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