Lassa virus vaccine induces rapid protection in an animal model Lassa Virus AnimalModel Vaccine NatureComms institutpasteur UniversiteLyon INSERM univ_paris_cite
The study is published in the journal Nature Communications.
The natural habitat of the Lassa virus is rodents of the Mastomys genera. The animal to human transmission occurs upon exposure to rodent-contaminated dust and infectious fluids. Although supportive care and symptomatic treatment appear to improve survival in Lassa virus-infected patients, no effective vaccines are currently available against this deadly disease.
Previous studies have shown that a single shot of this vaccine is highly effective in inducing a robust immune response and protecting against different strains of the Lassa virus in monkeys. The findings of clinical examinations revealed no clinical deterioration in vaccinated animals, whereas, non-vaccinated animals showed clinical symptoms including shivering, balance issue, and raised body temperature. One hour after the viral challenge, the animals vaccinated also exhibited clinical abnormalities, including nosebleeds.
Furthermore, no trace of infectious virus was detected in the blood and other organs of vaccinated animals. In contrast, non-vaccinated and 1-hour post-vaccinated animals exhibited increased titers of infectious virus and viral RNA in the blood and other organs.
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