Landmark Alliance results offer Tenofovir guidance in HIV/HBV co-infection AIDS2022
Interim results of ALLIANCE, the first head-to-head trial comparing two different tenofovir-containing antiretroviral regimens for the treatment of HIV and hepatitis B co-infection, demonstrate the superiority of bictegravir/emtricitabine/tenofovir alafenamide over dolutegravir plus tenofovir disoproxil fumarate , researchers reported here at the 24th International AIDS Conference .
The ongoing phase 3, multi-country study has 48-week results for 243 participants, who were HIV/HBV coinfected and treatment naïve. All subjects received three pills of ART per day, with blinded randomization to . The primary endpoints at 48 weeks were proportion of participants with HIV-1 RNA < 50 copies/mL and plasma HBV DNA < 29 IU/mL.
No participant developed treatment-emergent HIV-1 drug resistance while on B/F/TAF, and there were few study-drug related AEs or discontinuations, she reported. “The lower response rate of the TDF group is still poorly understood,” agreed Avihingsanon, emphasizing that “HBV and HIV/HBV are not the same, and TDF and TAF are also different. TAF has slightly more drug-drug interactions than TDF. I guess its end product in the liver might be higher. What is exciting to me is that there was such a high rate of HBsAg loss and HBs seroconversion in HIV/HBV coinfection, which is totally different from HBV monoinfection .
Österreich Neuesten Nachrichten, Österreich Schlagzeilen
Similar News:Sie können auch ähnliche Nachrichten wie diese lesen, die wir aus anderen Nachrichtenquellen gesammelt haben.
Abortion rights: President Biden to sign executive order aimed at safeguarding accessThe executive order also aims to give guidance to health care providers.
Weiterlesen »
Abortion rights: President Biden to sign executive order aimed at safeguarding accessThe executive order also aims to give guidance to health care providers.
Weiterlesen »
Abortion rights: President Biden to sign executive order aimed at safeguarding accessThe executive order also aims to give guidance to health care providers.
Weiterlesen »
San Francisco trans entrepreneurs get head start with accelerator programThe Transgender District was founded by three Black trans women in 2017 — Sa’id, honeymahogany and Janetta Johnson — and focuses on six program initiatives. Read more ⬇️
Weiterlesen »
Neighbors want plan from city for landmark Cleveland street that’s in disrepairNeighbors want plan from city for landmark Cleveland street that’s in disrepair
Weiterlesen »
Bank of America says AMD is still a buy even after disappointing guidanceInvestors should continue to bet on Advanced Micro Devices despite the chipmaker's disappointing forecast for the current period, Bank of America says.
Weiterlesen »