The trial that could transform care for people with blood disorders such as sickle cell and rare blood types.
Around half a million stem cells can result in 50 billion red blood cells. The latter is then filtered down to 15 billion red blood cells - the entire process takes three weeks, according to the publication.being infused is around 0.16-0.33 ounces - about one to two teaspoons.
The trial then compares the lab-grown cells' longevity with infusions of standard red blood cells from the same donor. The team expects the lab-grown cells to perform better as they are newly minted. Also, if the manufactured cells are seen to last longer in the body, patients who require blood regularly will not even require transfusions as often. This will go a long way in reducing the "iron overload" from frequent blood transfusions.The two people who have been transfused with lab-grown red cells are reported to be healthy, with no untoward side effects.
A minimum of ten participants will receive two mini transfusions at least four months apart, one of the standard donated red cells and one of the lab-grown red cells, "to find out if the young red blood cells made in the laboratory last longer than cells made in the body," said the release. Though the trial is a solid step towards the possibility of lab-grown red cells as a clinical product, manufactured cells can only be used for a tiny segment of patients dealing with complex transfusion needs.who have developed antibodies against most donor blood types. However, we should remember that the NHS still needs 250 blood donations every day to treat people with sickle cell, and the figure is rising.
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