AF screening, BNP, a new SGLT2 inhibitor, a sky-is-blue study, and the UK Mini Mitral surgical trial are discussed in this week's podcast.
Let’s do a brief recap of LOOP, which randomized about 6000 patients to an
Patients with high BNP may have more benefit from detecting AF and treating with OAC, but the opposite of benefit is harm—from OAC-related bleeding. So any benefit may be countered by harm. Having an BNP level above the median was associated with a higher risk of having AF discovered—in both groups. But in those individuals who had lower than median BNP, AF screening had no reduction in stroke or SE. HR 1.11.In both cases the p-value for interactions were significant.
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