To discover whether a true pediatric hepatitis outbreak is unfolding, a WHO team led by infectious disease physician Philippa Easterbrook aims to launch a survey of hepatologists around the globe.
The information that is really missing is on past COVID infection in these children. … [That’s] difficult to get and difficult to interpret because there was so much COVID transmission going on in late December 2021 and early 2022. [CDC recently reported that anhad been infected by February.] Most children will be positive [when tested for antibodies that indicate a previous SARS-CoV-2 infection.] So, it’s difficult to prove a point there.
Q: How do you reconcile the CDC report indicating no apparent U.S. outbreak with the apparently large numbers in the United Kingdom and the ambiguousness of data from other countries? We have always known there is this phenomenon of acute hepatitis of unknown [cause] in children.
Most of the [other] in-depth scientific investigations are inevitably going to be done in the high-income countries with a lot more cases, that have access to genetic sequencing, to host genomics, metagenomics, and toxicology studies. We are asking countries that are reporting cases to … please store samples. … [WHO this month] launcheddoi: 10.1126/science.add7043
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