Is depression associated with gut mycobacteria dysbiosis in children?

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Is depression associated with gut mycobacteria dysbiosis in children?
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Is depression associated with gut mycobacteria dysbiosis in children? depression microbiome mycobiome fungus childhealth childrenshealth childmentalhealth mentalhealth news

By Tarun Sai LomteApr 4 2023Reviewed by Lily Ramsey, LLM In a recent study published in the Journal of Affective Disorders, researchers from Zhejiang University, China, evaluated the gut mycobiota in adolescents/children with depression.

Previously, the authors reported fungal composition alterations in depressive adults. Interactions between bacteria and fungi have also been reported, including biofilm formation in vitro. Moreover, some commensal bacteria induce antifungal peptide secretion by epithelial cells in the colon. The researchers used internal transcribed spacer amplicon sequencing for the gut mycobiome analysis. The ITS sequence data were processed, and operational taxonomic units were identified.

The Alpha diversity was not significantly different between groups. Distinct clusters were observed for each group in Bray-Curtis and PCoA plots. Unweighted UniFrac distances did not differentiate the two groups. The researchers found no differences in the Alpha diversity between patients using psychotropic drugs and drug-naïve patients. Further, hierarchical clustering did not segregate drug-naïve patients from those using drugs.

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