Intelligent Nanodevice Delivers Insulin With High Accuracy AdvSciNews
By Dr. Priyom Bose, Ph.D.Mar 28 2023Reviewed by Megan Craig, M.Sc. Accurate insulin-delivery platforms responsive to blood glucose fluctuations are required to control hyperglycemia. Such platforms would also effectively prevent hypoglycemia diabetes. Recently, scientists from RMIT University, Monash University, the Baker Institute, and the University of Melbourne collaborated and developed a nanotechnology-based insulin delivery platform sensitive to glucose fluctuations.
A desirable insulin delivery system should also be equipped with adequate insulin-loading capacity with colloidal stability for storage. In addition, this system must have a long shelf-life and be cost-effective. As per the manufacturing process, it is extremely important that it is reproducible, simple, and biodegradable, with low immunogenicity and toxicity.
Developing A New Artificial Pancreas System Using Nanosugar The multidisciplinary research team developed a new artificial pancreas system using nanosugar. The nanosugar, i.e., phytoglycogen , used to develop the glucose-responsive NP system, was extracted from sweetcorn. The charge-switchable PG NPs, which have been referred to as PGEDA-FPBA NPs, were chemically synthesized using 4-Carboxy-3-fluorophenylboronic acid and ethylenediamine .
The mechanism of action of the engineered PGEDA-FPBA NCs was determined based on biodistribution, single-molecule localization microscopy, and pharmacokinetics. It was found that Ins-PGEDA-FPBA NCs can rapidly sense high glucose levels and, subsequently, enable quick in situ insulin deployment via a surface charge switch mechanism.
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