Inhibiting Ovarian Cancer Growth Using Gold Nanoparticles AdvSciNews cancer ovariancancer cancerresearch cancermedicine nanomedicine nanomaterials
By Bhavna KavetiSep 20 2022Reviewed by Susha Cheriyedath, M.Sc. High-grade serous ovarian cancer is among the deadliest human cancers and its prognosis remains extremely poor.
Furthermore, an orthotopic patient-derived xenograft model was used to confirm that the gold nanoparticles inhibited tumor growth in patients with HGSOC. Moreover, to validate the molecular mechanisms underlying the efficacy of gold nanoparticles, a cell line-based human xenograft tumor was treated with gold nanoparticles and PI-103 , individually and as a combination therapy .
Related StoriesMajor efforts in biomedical nanotechnology have focused on drug delivery and biosensor applications. Although the size- and shape-dependent physicochemical and optoelectronic properties of inorganic nanoparticles have been studied in detail, their biological properties remain practically unexplored.
Previously, the self-therapeutic properties of 20-nanometer gold nanoparticles that inhibited tumor growth in two preclinical orthotopic models of ovarian cancer were demonstrated. This took place through through the inhibition of mitogen-activated protein kinase -activation and reversal of epithelial-mesenchymal transition via downregulation of several heparin-binding growth factors.
Exploring the modulation of the protein corona around gold nanoparticles helped identify various new targets, including hepatoma-derived growth factor , survival motor neuron domain containing 1 , inorganic pyrophosphatase , peptidase inhibitor 15 , gasdermin B, and insulin-like growth factors in ovarian cancer.
Conclusion In conclusion, a new regulatory protein, IGFBP2, was identified that facilitated the gold nanoparticles to impair the development and progression of ovarian cancer. Based on the non-toxic dose of gold nanoparticles, the suppression of tumor growth in an orthotopic PDX model mouse was demonstrated.
Österreich Neuesten Nachrichten, Österreich Schlagzeilen
Similar News:Sie können auch ähnliche Nachrichten wie diese lesen, die wir aus anderen Nachrichtenquellen gesammelt haben.
Customizing Pt5Ce Alloy Particle Sizes for Oxygen ReductionResearchers have discovered that customizing the size of Pt5Ce alloy nanoparticles enables an oxygen reduction reaction.
Weiterlesen »
Is aspirin linked to higher rates of survival for cancer patients?Is aspirin linked to higher rates of survival for cancer patients? RSocPublishing cardiffuni cancer aspirin medicalresearch disease
Weiterlesen »
How left-wing on economics is Luiz Inácio Lula da Silva?An interview on spending and growth with the frontrunner to be Brazil’s next president
Weiterlesen »
Study develops single-use microneedle patch tattoos with wide-ranging application potentialResearchers developed a rapid, sterile, and painless method of tattooing using single-use microneedle tattoo patches, which can be used for cosmetic and veterinary applications and storing medical information.
Weiterlesen »
Yorkshire police force questioned about use of facial recognition software“Confirming or denying whether any other information is or isn’t held relating to the covert use of facial recognition technology would limit operational capabilities,” its response stated.
Weiterlesen »