Canadian researchers found that patients with immune-mediated inflammatory diseases (IMIDs) don't face a heightened risk of venous thromboembolism events after recovering from COVID-19 compared to those without IMIDs. However, certain comorbidities can influence this risk, emphasizing the importance of individualized patient care.
By Dr. Chinta SidharthanOct 11 2023Reviewed by Susha Cheriyedath, M.Sc. In a recent study published in the journal JAMA Network Open, researchers in Canada investigated whether coronavirus disease 2019 patients with immune-mediated inflammatory diseases were at a higher risk of experiencing venous thromboembolism events after recovering from severe acute respiratory syndrome coronavirus 2 infections as compared to COVID-19 patients without IMIDs.
The inflammation in IMID patients causes platelet abnormalities, endothelial dysfunction, fibrinolysis impairments, and abnormal activation of coagulation factors. Recent evidence also indicates that the widespread inflammation and endothelial dysfunction caused by COVID-19 are associated with a higher risk of venous thromboembolisms and multiorgan failure in patients who have recovered from moderate to severe SARS-CoV-2 infections.
In the retrospective matched cohort analysis, the researchers matched individuals who had IMIDs and had tested positive for COVID-19 with up to five individuals who had tested positive for COVID-19 but did not have IMIDs. The controls were matched based on factors such as age, sex, urban or rural residence, and the mean income quantile of the neighborhood. Individuals with malignant neoplasm diagnoses five years after a positive COVID-19 test were excluded from the study.
Results The findings suggested that individuals with IMIDs did not have a significantly higher risk of venous thromboembolisms after recovering from SARS-CoV-2 infections as compared to individuals without IMIDs. Among the 28,440 individuals with IMIDs who were included in the study, the incidence of venous thromboembolism events was 2.64 per 100,000 person days, while in the matched cohorts of individuals without IMIDs, it was 2.18 per 100,000 person days.
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