There was an increase in new-onset pediatric diabetes and DKA during the year of the early COVID-19 pandemic compared with the prior year. EndoTwitter
in children have involved small cohorts and did not explore DKA incidence and severity in children with pre-existing type 1 diabetes during the COVID-19 pandemic.The DIMPLES study is a retrospective multicenter study conducted across 49 sites in the UK and Ireland.
Researchers compared characteristics of children aged 6 months to 16 years presenting to the ED with new-onset or pre-existing diabetes with DKA during the early COVID-19 pandemic with those of the preceding year .There was a 17% increase in new-onset diabetes from Year 1 to Year 2, mostly of type 1 diabetes.There was a 43% increase in severity of new-onset disease from Year 1 to Year 2, with severe DKA increasing by 79% and intensive care admissions by 89% .
Of the 873 children with new-onset diabetes, 12 tested positive for SARS-CoV-2. DKA was severe in four, moderate in three, and mild in three. Of the 155 children with pre-existing diabetes, four tested positive for SARS-CoV-2. DKA was severe in two, moderate in one, and mild in one, and none had delayed presentation. There was no difference in median diagnostic interval for children presenting with new-onset diabetes during the pandemic compared with the prior year .Limited availability of SARS-CoV-2 testing may have led to underestimation of impact of virus on reported outcomes.
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