Pfizer is testing an extra dose of its COVID-19 vaccine for babies and preschoolers after preliminary research hinted the usual two doses wouldn't be enough.
Pfizer reports that a lower dose of its COVID-19 vaccine did not produce a potent immune response in children 2 to 4. Here’s what we know.
For children younger than 5, Pfizer is testing an even smaller dose, just 3 micrograms or one-tenth of the adult dose. Researchers analyzed a subset of youngsters in the study a month after their second dose to see if the tots developed levels of virus-fighting antibodies that were similar to teens and young adults who get the regular shots.
The very low-dose shots appeared to work in youngsters under age 2, who produced similar antibody levels. But the immune response in 2- to 4-year-olds was lower than the study required, Pfizer vaccine research chief Kathrin Jansen said Friday in a call with investors. Rather than trying a higher-dose shot for the preschoolers, Pfizer decided to expand the study to evaluate three of the very low-dose shots in all the study participants — from 6 months up to age 5. That third shot will come at least two months after the youngsters’ second dose.
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