The therapy will now be tested in larger trials.
Five patients with hard-to-treat lupus entered remission after scientists tweaked their immune cells using a technique normally used to treat cancer. After the one-time therapy, all five patients with the autoimmune disease stopped their standard treatments and haven't had a relapse.
"It's a single shot of CAR T cells and patients stop all treatments," Schett told Live Science."We were really surprised [at] how good this effect is." Rebooting the immune system Lupus is a chronic disease in which the immune system inadvertently attacks the body's own cells, resulting in inflammation, tissue damage, pain and fatigue.
Schett's group theorized that such treatment-resistant lupus patients could potentially benefit from CAR T-cell therapy, which has previously been used to treat cancer patients. During CAR T-cell therapy, doctors extract immune cells, called T cells, from a patient's blood, genetically tweak those T cells in the lab and then inject them back into the patient's body, according to the NIH's National Cancer Institute .
The other four patients' also started making new B cells within months of treatment, without relapsing. It seems as though rebooting the B cell system in this way may prevent the disease from coming back — but they'll need to keep monitoring the patients to be sure, Schett said.—A cancer 'vaccine' cured 97% of tumors in mice. What's that mean for people?"The mean follow up of 8 months is too early to determine whether this is complete remission," said Dr.
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