A strong T-cell response against the coronaviruses that cause common cold-like symptoms has been linked to greater covid-19 immunity
Da Silva Antunes says it was important to use samples taken before the pandemic. “This means that when we’re looking at our results, we know that they are caused by pre-existing immune memory and that they’re not contaminated by people’s immune responses to SARS-CoV-2.”
By looking at the T-cells, some of which are more likely to be activated by recent re-infections, they determined these immune responses weren’t due to regular re-infections. Instead, this immune response may be relatively stable. But the participants with stronger responses against common cold-like coronaviruses weren’t necessarily less likely to experience severe covid-19, says da Silva Antunes. “The link between [the common] cold response and SARS-CoV-2 response is still not clear,” he says. Assuming most people have been exposed to common cold-like coronaviruses throughout their life, it isn’t clear why some still become severely ill with covid-19.
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