Newly discovered genes could explain body fat differences between men and women with obesity, as well as why some people gain excess weight in childhood.
Aug. 8, 2023 –
Although the study is not the first to point to specific genes, “we were quite surprised by the proposed function of some of the genes we identified,” Lena R. Kaisinger, lead study investigator, wrote in an email. For example, the genes also manage cell death and influence how cells respond to DNA damage, said Kaisinger, a PhD student in the MRC Epidemiology Unit at the University of Cambridge School of Clinical Medicine, U.K.
“The key thing is that when you see real genes with real gene names, it really makes real the notion that genetics underlie obesity,” said Lee Kaplan, MD, PhD, director of the Obesity and Metabolism Institute in Boston, who was not affiliated with the research. “We know that different types of obesity connect to different ages,” said Kaplan, who is also past president of the Obesity Society, a 2,800-member professional group focused on obesity science, treatment and prevention. “But what they've done now is find genes that are associated with particular subtypes of obesity … some more common in one sex and some more common in different phases of life, including early onset obesity.”Treatment for obesity based on a person's genes already exists.
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