Faecal transplants have helped some people to overcome resistance to powerful immunotherapies. Now dozens of trials are taking aim at the cancer–microbiome
Cancer cells co-cultured with bacteria : many tumours have their own microbiome, which might interact with microbes in other parts of the body.Microbes travel to tumours from many areas — including the gut, the oral cavity and the bloodstream — depending on the cancer, says Boursi. “We think there are different origins,” says Florencia McAllister, an oncologist at the MD Anderson Cancer Center.
Epidemiological studies around the world show that diet influences gut-microbiome profiles even more so than do people’s genes, says Christine Spencer, director of informatics at the Parker Institute for Cancer Immunotherapy in San Francisco, California.
Shany’s FMT came from the lone, full responder in the first Israeli clinical trial, making Shany, essentially, a second-generation recipient of Levy’s donation. Not only did the immunotherapy work, but its side effects were minimized, much to Shany’s relief.
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