Alpine altitude climate treatment may help people with asthma that remains severe despite maximum guideline-adherent treatment.
, Fieten and her colleagues used the standard medical research databases to review the literature on physical characteristics of altitude, environmental characteristics of the alpine climate, and immunological and clinical outcomes.
The lower barometric pressure, inspiratory oxygen pressure, and air density, along with the relatively low temperature and humidity, and the increased ultraviolet radiation, induce immunologic and physiologic adaptation responses. And at higher elevations, house dust mites, pollen, fungi, air pollution, and other aeroallergens are reduced.
"The specific effectiveness of AACT may lie in the observed rapid decrease in inflammation, either because of fewer environmental triggers in the alpine climate or physical altitude climate factors and their immunomodulatory effects, or because of other yet unknown mechanisms," the authors write. "One limitation noted by the authors is the lack of studies that included randomized controlled trials comparing AACT to other pulmonary rehabilitation programs," added Ray, who was not involved in developing the position paper.
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