Personalized bloodpressure treatment more effective, study finds UU_University JAMA_current
Is there a potential for personalized drug therapy in hypertension, and, if so, what is the magnitude of the benefit of personalization?In this randomized, double-blind, repeated crossover trial, the blood pressure response to treatments varied substantially between individuals. It was estimated that personalized treatment choice would on average lead to 4.4 mm Hg–lower systolic blood pressure than a fixed choice.
Mixed-effects models were used to assess the extent to which individuals responded better to one treatment than another and to estimate the additional blood pressure lowering achievable by personalized treatment.Each participant was scheduled for treatment in random order with 4 different classes of blood pressure–lowering drugs , with repeated treatments for 2 classes.Ambulatory daytime systolic blood pressure, measured at the end of each treatment period.
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