Through DNA sequencing of Tasmanian devils and their tumors, researchers have tracked the genomic interactions between the animals and the cancer.
Over the past 30 years, Australia's Tasmanian devil population has been afflicted with an infectious cancer that has pushed the species to near extinction. The marsupials are highly susceptible to devil facial tumor disease, which is almost always fatal to their species. The genomic interactions between the disease and its host correlate with how quickly a susceptible animal becomes infected after exposure to the pathogen.
Using a recently developed joint genome-wide association study, Margres and Gallinson assessed 960 genomes and 15 years of data on captured devils to track the co-evolution of the devils and the cancer. Their findings can inform both epidemiological models that track infectious diseases and devil management strategies that focus on saving the endangered species.Dylan G. Gallinson, Christopher P. Kozakiewicz, Rhett M. Rautsaw, Marc A. Beer, Manuel Ruiz-Aravena, Sebastien Comte, David G. Hamilton, Douglas H. Kerlin, Hamish I. McCallum, Rodrigo Hamede, Menna E. Jones, Andrew Storfer, Ryan McMinds, Mark J. Margres.
Researchers have found strong evidence that a transmissible cancer that has decimated Tasmanian devil populations likely won't spell their doom. For the first time, a research team employed genomic ...
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