Genetics of pretermbirth and pregnancy length clarified NatureGenet
) and—even more importantly—achieve the goal of preventing preterm births.
Bo Jacobsson, professor of obstetrics and gynecology at Sahlgrenska Academy, University of Gothenburg, and senior consultant doctor at Sahlgrenska University Hospital, led the study. His previous advances in this area were already acclaimed.The minimal margins in a human birth set us apart from other mammals. A woman's pelvis barely allows a fully grown fetus to pass through; in contrast, a female chimpanzee's pelvic passage, for example, has twice the diameter as that of her young.
"The results have given us more routes to understanding how labor is initiated, both at full term and in premature labor. In samples, we were able to identify numerous previously undiscovered genetic variants associated with the timing of parturition, and these provide unmatched insights into the underlying biological mechanisms," Jacobsson notes.To understand whether gestational duration is determined by the genes of the woman or the fetus, we examined 136,833 cases.
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