Gut microbiota, Alzheimer's and the central nervous system SciReports
GordonibacterThe strength of our study include the use of the largest available GWASs of gut microbiota taxa to date that allow us to identify multiple genera genetically associated with AD after the strict Bonferroni correction. The use of logistic regression analysis alongside our initial PRS analyses allowed us to adjust for potential confounders, such as sex, age, andalleles, and further validate that the association was independent of those confounders.
Second, our genotyping data for AD studies were mostly drawn from European American individuals, which limits the generalization of our conclusions when applied to other ethnic groups. Although the largest ethnic cohort of the MiBioGen GWAS was European , the inclusion of other ethnic groups in the original study’s meta-analysis may be a confounding factor in our results. More diverse genotyping datasets would enable us to capture the variability in risk for AD across different ethnicities.
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