Fine-tuning 3D lab-grown mini tumors to help predict how patients respond to cancer therapies NatureComms
"Tumor organoids have become fundamental tools to investigate tumor biology and highlight drug sensitivities of individual patients," said Alice Soragni, Ph.D., an assistant professor in the department of Orthopaedic Surgery at the David Geffen School of Medicine at UCLA and member of the UCLA Jonsson Comprehensive Cancer Center.
To overcome these challenges, the team of researchers created a method that uses a bioprinting technique to print cells in a thin layer of support extra-cellular proteins to give rise to 3D mini-tumors without altering the tissue histology and gene expressions. The team combined bioprinted cells with high-speed live cell interferometry , an imaging system that is a non-destructive approach used to observe and measure the weight of living cells in real-time.
With the new method combination, researchers confirmed that they could measure the growth patterns of the bioprinted"The measurements were done in a way that did not damage or destroy the organoids, allowing for non-invasive analysis of their growth and drug responses," noted Teitell.
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