Measuring the levels of 184 fat molecules in the blood could improve how we assess people’s risk of developing diabetes and cardiovascular disease
that ran from 1991 to 2015 in Sweden. Their blood samples were analysed with a mass spectrometer to measure the levels of 184 fats – also known as lipids.
They used the models to calculate disease risk scores from lipid levels in the remaining third of people who weren’t included in the training data set. They found that the 10 per cent of people predicted by the new approach to be at highest risk of type 2 diabetes had a 168 per cent higher rate of the disease, compared with the average rate across the study group.
“We need multiple ways to capture the risk [of type 2 diabetes and cardiovascular disease] in a precise manner for an individual. Risk scores [calculated from fat profiles] may well turn out to be a new and efficient tool for prevention of these diseases with great societal burden,” saysMore studies are needed to confirm the results and establish whether these fats in the blood cause disease themselves, or reflect other changes to body metabolism that lead to disease.
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